Publications

Rui Costa

Research Papers

• Dias-Ferreira, E., Sousa, J.C., Melo I., Morgado P., Mesquita, A.R., Cerqueira J.J., Costa, R.M., Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making. Science, 325(5940):621-5.

• Yin, H.H., Prasad-Mulcare, S., Hilario, M.R.F., Clouse, E., Davis, M. I., Lovinger, D.M.., Costa, R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3.

• Cui, Y., Costa R. M., Murphy G. G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.

• Groszer, M., Keays, D.A., Deacon R.M.J., de Bono J.P., Prasad-Mulcare S., Gaub, S., Baum, M.G., French, C.A., Nicod, J., Coventry, J.A., Enard, W., Fray, M., Brown, S.D.M., Nolan, P.M., Pääbo, S., Channon, K.M., Costa, R. M., Eilers, J., Ehret, G., J., Rawlins N.P., Fisher, S.E. (2008). Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits Current Biology, 18(5):354-62.

• Hilario, M.R.F., Clouse, E., Yin, H.H., Costa, R.M. (2007). Endocannabinoid signaling is critical for habit formation. Frontiers in Integrative Neuroscience. 1:6, doi: 10.3389/neuro.07/006.2007.

• Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr, M., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52(2):359-69.

• Dzirasa, K., Ribeiro. S., Costa, R., Santos, L.M., Lin, S.C., Grosmark, A., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Dopaminergic Control of Sleep-Wake States. Journal of Neuroscience, 26(41):10577-89.

• Costa, R.M., Gutierrez, R., Kloth, A., Coelho, M.R.P., de Araujo, I.E., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L., Simon, S.A. (2007). Dopamine levels modulate the updating of tastant values. Genes, Brain and Behavior, 6(4):314-20.

• Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R.M., Silva, A. J., Kaczmarek, L., and Huntley G. W. (2006). Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. Journal of Neuroscience, 26: 1923-1934.

• Costa, R.M., Liu, L., Nicolelis, M.A.L., Simon, S.A. (2005). Gustatory Effects of Capsaicin that are Independent of TRPV1 Receptors. Proc. ISOT XIV, Chemical Senses, 30 S1:i198-i200.

• Israely, I., Costa, R.M., Silva, A.J., Kosik, K., Liu, X. (2004). Deletion of the neural specific protein Delta-Catenin leads to severe cognitive and synaptic dysfunction. Current Biology, 14(18):1657-63.

• Costa, R.M.*, Cohen, D.*, Nicolelis M.A.L. (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Current Biology, 14(13):1124-34.

• Costa R.M., Honjo T., and Silva A.J. (2003). Learning and memory deficits in Notch mutant mice. Current Biology, 13 (15): 1348-54.

• Ajay A., Costa R.M., Irvin D., Patel A., Hu H., Kornblum H., Silva A.J., O’Dell T., and Colicelli J. (2003). The RAS Effector RIN1 Modulates the Formation of Aversive Memories. Journal of Neuroscience, 23 (3): 748-757.

• Costa, R.M., Federov, N.B., Kogan, J.H., Murphy, G.G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415 (6871):526-30.

• Givogri M.I., Costa R.M., Schonmann V., Howard S., Silva A.J., Campagnoni A.T., Bongarzone E.R. (2002) The Jagged/Notch pathway is critical for oligodendrocyte differentiation and myelination in vivo. Journal of Neuroscience Research, 67 (3):309-20.

• Ohno, M., Frankland, P.W., Chen, P.A., Costa R.M. and Silva A.J. (2001). Inducible pharmacogenetic approaches to the study of learning and memory. Nature Neuroscience, 4, 1238-1243.

• Costa, R.M.*, Yang, T.*, Huynh, D.P., Pulst S.M., Viskochil, D.H., Silva, A.J. and Brannan, C.I. (2001). Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene. Nature Genetics, 27, 399-405.

• Mayntz, M. and Costa, R. (1998). Effect of pharmacologically induced changes of ejection on suckling in Bos taurus. Physiology and Behavior, 65 (1), 151-156.

• Costa, R., Mayntz, M. and Sender, G. (1998). Changes of milk compounds and fatty acid composition during suckling meals and the effect of after-stimulation on fatty acid composition in cows’ milk. A pre-study. Milchwissenchaft, 53 (8), 430-434.

Review papers

• Hilário, M.R.F and Costa, R.M. (2008). High on Habits. Frontiers in Neuroscience, 2,2:208-21

• Wickens, J.R., Horvitz, J.C., Costa, R.M., Killcross, S. (2007). Dopaminergic mechanisms in actions and habits. Journal of Neuroscience, 27:8181-3

• Costa, R.M., (2007). Plastic corticostriatal circuits for action learning: What’s dopamine got to do with it? In: Reward and Decision Making in Corticobasal Ganglia Networks Annals of the New York Academy of Sciences, 1104:172-91.

• Costa, R.M., Drew, C. and Silva, A.J. (2005). To Remember or Notch to Remember. Trends in Neurosciences, 28, 429-35.

• Costa, R.M. and Silva, A.J. (2003). Mouse models of Neurofibromatosis type I: Bridging the GAP. Trends in Molecular Medicine, 9, 19-23.

• Frankland, P.W., Ohno M., Takahashi, E., Chen, A.P., Costa R.M., Kushner, S.A. and Silva, A.J. (2003). Synomics: Pharmacologically Regulated Induction of Silent Mutations (PRISM): Combined pharmacological and genetic approaches for learning and memory. The Neuroscientist, 9:104-9.

• Costa, R.M. and Silva, A.J. (2002). Molecular and cellular mechanisms underlying the cognitive deficits associated with Neurofibromatosis type I. Journal of Child Neurology, 17, 622-626.

• Silva, A.J., Elgersma, Y. and Costa, R.M. (2001). From genes to therapies: the role of animal models. Clinical Neuroscience Research, 1, 187-193.

• Silva, A.J., Elgersma, Y. and Costa, R.M. (2000). Molecular and Cellular Mechanisms of Cognitive Function: Implications for Psychiatric Disorders. Biological Psychiatry, 47, 200-210.

Book Chapters and Monographs

• Costa, R.M,. and Silva, A.J. (2004). Learning Deficits associated with NF1: from models to therapies. in Neurofibromatose: Clínica, Genética e Terapêutica , Ed. Mauro Geller, Editora Guanabara Koogan SA, Rio de Janeiro, Brazil (Portuguese).

• Costa, R.M., Elgersma, Y. and Silva, A.J. (2003). Modeling cognitive disorders: from genes to therapies. in Genetics and Genomics of Neurobehavioral Disorders , Ed. Gene Fisch, Humana Press, Totowa, NJ, USA

• Costa, R.M. (2002). Molecular and cellular mechanisms of cognitive dysfunction in Neurofibromatosis type I. Thesis. Abel Salazar Biomedical Institute, University of Porto, Portugal.