The dynamical basis of working memory
In order to guide behaviour, it is sometimes necessary to actively maintain or manipulate information which has been previously experienced, but is no longer present in the environment – an ability referred to as Working Memory. The prefrontal cortex has been identified as a key brain area in this process, and recent work is suggesting an important role for sensory areas in working memory as well.
In this project we are interested in characterising the structure of working memory representations at the population level, in quantifying their dynamical stability, and in investigating the contribution of sensory and frontal areas to working memory function in mice. Our goal is to combine careful behavioural analysis, electrophysiology, optogenetics and modeling to provide a dynamical foundation for this important cognitive ability.