RESEARCH GROUPS
Neurobiology of Action

ABOUT

Neurobiology of Action

Costa Lab

To study actions is to study the way we do things, which is different than studying how we remember stimuli, or facts and events. Some actions are innate or pre-wired (like swallowing or breathing). Others are learned anew throughout life, likely through a process of trial and feedback. We currently focus on understanding the processes mediating the latter.

A growing body of evidence suggests that cortico-basal ganglia circuits are involved in action generation and selection, in skill learning, and in learning goal-directed actions and habits. We center our efforts on investigating the cortico-basal ganglia mechanisms underlying these processes using an across-level approach, from molecules to circuits.

We chose to implement this integrative approach in mice because they combine the power of genetics, a mammalian brain with canonical cortico-basal ganglia loops that can generate and propagate oscillatory activity, and the possibility of accurately quantifying simple behaviors like action initiation (with EMG recordings or using inertial sensors) and stereotypic skill learning, and more elaborate behaviors like goal-directed actions.

Info

Main Interests

How the brain generates and selects actions

Methods

Optogenetics, electrophysiology, behaviour

Models and Regions

Rodents; Humans / Basal Ganglia; Orbitofrontal Cortex

Opportunities

If you are interested in joining our group, please contact Rui Costa at the email address bellow.

rui.costa@neuro.fchampalimaud.org

Lab Webpage

costa-lab.org

TEAM

Neurobiology of Action

Know our Team

Rui Costa

Rui Costa, DVM, PhD

Principal Investigator

Nuno Loureiro

Nuno Loureiro

2012 INDP PhD Student

Thomas Akam

Thomas Akam, PhD

External Postdoctoral Fellow

Ana Isidro

Ana Isidro

Masters Student

Ana Rita Afonso

Ana Rita Afonso

Masters Student

Sara de Oliveira

Sara de Oliveira

Masters Student

Ana Castro

Ana Castro

PhD Student

Ivo Marcelo

Ivo Marcelo

PhD Student

Joaquim Alves da Silva

Joaquim Alves da Silva

PhD Student

Marcelo Mendonça

Marcelo Mendonça

PhD Student

Ana Cruz

Ana Cruz, PhD

Postdoctoral Fellow

Ana Fernandes

Ana Fernandes, PhD

Postdoctoral Fellow

Andreas Klaus

Andreas Klaus, PhD

Postdoctoral Fellow

Catarina Carvalho

Catarina Carvalho, PhD

Postdoctoral Fellow

Catherine French

Catherine French, PhD

Postdoctoral Fellow

Cristina Afonso

Cristina Afonso, PhD

Postdoctoral Fellow

Cristina Álcacer

Cristina Álcacer, PhD

Postdoctoral Fellow

Nicolas Morgenstern

Nicolas Morgenstern, PhD

Postdoctoral Fellow

Rodrigo Oliveira

Rodrigo Oliveira, PhD

Postdoctoral Fellow

Sevinç Mutlu

Sevinç Mutlu, PhD

Postdoctoral Fellow

Vítor Paixão

Vítor Paixão, PhD

Postdoctoral Fellow

Daniela Pereira

Daniela Pereira, PhD

Research Scientist

Margarida Nunes

Margarida Nunes

Lab Administrator

PUBLICATIONS

Know our Publications