Fluid Memory: Explorations in Hippocampal Replay

Host

Daniel McNamee, PhD, Natural Intelligence Lab

Venue

Seminar room

Abstract

Hippocampal replay is widely thought to support goal-directed behavior, but its flexibility in complex, changing environments remains unclear. I will present results from a dynamic spatial task in which goal locations and barriers were altered across sessions. Using large-scale hippocampal recordings, we found that replay rapidly adapted to new configurations, generating novel, goal-directed sequences without place field remapping—revealing a dissociation between stable, sensory-driven place coding and flexible, memory-driven replay. Next, I will describe a simple continuous attractor network model with firing rate adaptation that accounts for recent experimental results on the 4spatio-temporal organization of hippocampal sequences during both rest (replay) and movement (theta sequences). Lastly, I will present preliminary results examining how hippocampal sequences behave on a classic reference frame switching task (Gothard et al., 1996) in which rats shuttle back and forth along a linear track that changes length randomly across trials.


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About CR Colloquia Series

Champalimaud Research (CR) Colloquia Series is a seminar programme organised by the Champalimaud Centre for the Unknown to promote the discussion about the most interesting and significant questions in neuroscience and physiology & cancer with appointed speakers by the CR Community.