The NextSeq 2000 is a flexible benchtop nextgeneration sequencing (NGS) platform that delivers highquality shortread data for a broad spectrum of genomics applications. It supports projects ranging from wholegenome and exome sequencing to targeted panels, transcriptomics, and singlecell analyses. The instrument provides scalable throughput, generating approximately 100 million to over 1 billion reads per run, with run times typically between 10 and 30 hours. Integrated DRAGEN informatics enable onboard primary and secondary analysis, streamlining the workflow from data generation to interpretation.