Tumor-Host Crosstalk: Immune-Metabolic Circuits in Pancreatic Cancer

We are dissecting the immune and metabolic dialogue between pancreatic tumors and their microenvironment. Leveraging ligand-receptor interaction modeling, spatial transcriptomics, and functional assays, this project focuses on how metabolic competition, immune evasion, and local nutrient dynamics influence tumour progression and therapeutic resistance. Emphasis is placed on uncovering immune cell states and metabolic pathways that mediate cachexia, immunosuppression, and response to immunotherapy.