Nicole explores how moving away from the “domino-chain” view of the brain toward seeing it as a complex dynamical system – full of feedback loops and interactions – is opening doors to exciting new discoveries. They talk about the challenges of measuring brain disorders, why fundamental research is so essential, and how predicting salmon populations can help predict seizures in the brain.

“The spinal cord isn’t just a passive relay station executing brain commands”, says Susana Lima, Principal Investigator of CF’s Neuroethology Lab and senior author of the study. “It integrates sensory inputs, responds to arousal, and adjusts its output based on the animal’s internal state. It’s much more sophisticated than we imagined”.

Nicole asks a provocative question: what if treating brain disorders is less like replacing a broken part in a machine, and more like trying to redirect a hurricane? Nicole argues that only by embracing the brain as a complex adaptive system can we hope to make real progress.