Command, Connect, Clean: Mapping Neural Circuits for Fly Grooming as a Model Motor Sequence

Host

Eugenia Chiappe, Principal Investigator, Champalimaud Research

Venue

Seminar Room

Abstract

How the nervous system coordinates complex behaviors remains a puzzle. Grooming behavior in the fruit fly Drosophila is a sequence composed of leg movements targeted to clean different body parts. Grooming is initiated by sensory cues and executed by motor circuits. There is an anterior to posterior progression based on a suppression hierarchy.  The wealth of genetic tools and anatomical resources make this behavior a powerful experimental model system to explore how innate, rhythmic, but flexible sequences are controlled by neural architecture we may share. I will present new work from my lab at UCSB starting from command-like neurons to uncover principles that organize this behavior as well as the circuits that implement them. I will briefly explain how forays into the connectome motivate my UK sabbatical project to design new genetic reagents to access neurons of interest. I look forward to discussion and feedback.

Biography

Julie H. Simpson received an AB from Princeton in Molecular Biology with research experience in fruit fly eye development. She did a year of rice viral genetics in Costa Rica, and then a PhD at UC Berkeley in axon guidance at the fly embryonic midline. After a post-doc at University of Wisconsin, Madison, studying temperature sensitive ion channels and screening for neurons affecting fly motor control, she was one of the early Group Leaders at the Janelia Research Campus of the Howard Hughes Medical Institute. She ran a research group using the new tools for targeting and manipulating neuronal activity with temperature and light to map circuits governing a range of behaviors. She joined UC Santa Barbara in 2015, where her lab performs genetic screens for critical neurons and circuits that govern fly grooming behavior. 

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About CR Colloquia Series

Champalimaud Research (CR) Colloquia Series is a seminar programme organised by the Champalimaud Centre for the Unknown to promote the discussion about the most interesting and significant questions in neuroscience and physiology & cancer with appointed speakers by the CR Community.