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About

Advanced Omics Platform

Advanced Omics Platform

The Advanced Omics Platforms utilizes a number of technologies to produce bulk, single cell and spatial omics data for researchers within the Wurth research laboratories at the Botton Champalimaud Pancreatic Cancer Centre.

INFO

Get in touch

To find out more about our lab, contact Craig Nourse via email.

Team

Advanced Omics Platform

Craig Nourse

Craig Nourse, PhD

Manager

Inês Sousa

Inês Sousa, PhD

Research Technician

Carla Oliveira

Carla Oliveira, PhD

Research Technician

Publications

Advanced Omics Platform

Fiorini E, Malinova A, Schreyer D, Pasini D, Bevere M, Alessio G, Rosa D, D'Agosto S, Azzolin L, Milite S, Andreani S, Lupo F, Veghini L, Grimaldi S, Pedron S, Castellucci M,Nourse C, Salvia R, Malleo G, Ruzzenente A, Guglielmi A, Milella M, Lawlor RT, Luchini C, Agostini A, Carbone C, Pilarsky C, Sottoriva A, Scarpa A, Tuveson DA, Bailey P, Corbo V. MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. Nature. 2025 Apr;640(8059):811-820. doi: 10.1038/s41586-025-08721-9. Epub 2025 Mar 12.

Astuti Y, Raymant M, Quaranta V, Clarke K, Abudula M, Smith O, Bellomo G, Chandran-Gorner V,Nourse C, Halloran C, Ghaneh P, Palmer D, Jones RP, Campbell F, Pollard JW, Morton JP, Mielgo A, Schmid MC. Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nat Cancer. 2024 May;5(5):774-790. doi: 10.1038/s43018-024-00731-2. Epub 2024 Feb 14.

Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R,Nourse C, Schoenherr C, Treanor-Taylor M, Healy E, Lai C, Craig P, Moyes C, Rickaby W, Martin J, Proby C, Inman GJ, Leigh IM. Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. J Am Acad Dermatol. 2023 Dec;89(6):1159-1166. doi: 10.1016/j.jaad.2023.08.012. Epub 2023 Aug 14.

Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G,Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ. Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nat Metab. 2023 Aug;5(8):1303-1318. doi: 10.1038/s42255-023-00857-0. Epub 2023 Aug 14.PMID: 37580540

Yang F, Nourse C, Helgason GV, Kirschner K. Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches. Hemasphere. 2023 May 26;7(6):e895. doi: 10.1097/HS9.0000000000000895. eCollection 2023 Jun.

 

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