Key Publications

Nwosu, Z., Ward, M., Sajjakulnukit, P., Poudel, P., Ragulan, C., Kasperek, S., Radyk, M., Sutton, D., Menjivar, R., Andren, A., Apiz-Saab, A.J., Tolstyka, Z, Brown, K., Lee, H., Dzierozynski, L.N., He, X., Ps, H., Ugras, J., Nyamundanda, G., Zhang L, Halbrook C, Shi, J., Shriver, L.P., Patti, G.J., Muir, A., Carpenter E, di Magliano M, Sadanandam A*, Lyssiotis C*. Nutrient profiling reveals uridine as a fuel for pancreatic cancer through uridine phosphorylase 1. Nature, 618, pages 151–158, 2023. *- Equal corresponding author

Collisson, E.A*., Sadanandam, A*., Olson, P., Gibb, W.J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G.E., Jakkula, L., Feiler, H., Ko, A.H., Olshen, AB., Danenberg, K.L., Tempero, M.A., Spellman, P.T., Hanahan, D., Gray, J.W. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Medicine, 17; 500 – 503, 2011 - included in Faculty of 1000. *- co-first author

Lan, L., Evan, T., Li, H., Hussain, A., Ruiz, E.J., Thin, M.Z., Ferreira, R., Ps, H., Riising, E., Zen, Y., Almagro, J., Ng, K., Soro-Barrio, P., Nelson, J., Koifman, G., Carvalho,J., Nye, E,, He, Y., Zhang, C.,, Sadanandam, A., Behrens, A. Grem1 restrains epithelial-mesenchymal plasticity to maintain cellular heterogeneity in pancreatic cancer. Nature, 2021.

Guinney J & ., Dienstmann, R & ., Wang, X.; ., de Reynies A.; ., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., Bot B.M., Morris, J., Simon, I.M., Gerster S., Fessler E., De Sousa E Melo, F., Missiaglia E., Ramay H., Barras D., Homicsko, K., Maru D., Manyam G.C., Broom B., Boige V., Perez-Villamil, B., Laderas, T., Salazar, R., Gray, J.W., Hanahan, D., Tabernero, J., Bernards, R., Friend, S.H., Laurent-Puig, P*., Medema*, J.P., Sadanandam, A*., Wessels, L*., Delorenzi, M*., Kopetz, S*., Vermuelen, L*., and Tejpar, S* (Colorectal Cancer Subtyping Consortium). The consensus molecular subtypes of colorectal cancer. Nature Medicine, 21; 135-1356, 2015 - included in the Faculty of 1000. *- co-senior authors.

Sadanandam, A., Lyssiotis, C.A., Homiscko, K., Collisson, EA., Gibb, W.J., Wullschleger, S., Ostos, L.C.G., Lannon, W.A., Grotzinger, C., Del Rio, M., Lhermitte, B.,
Olshen, A., Wiedenmann, B., Cantley, L.C., Gray, J.W, Hanahan, D. A colorectal tumor classification system that associates cellular phenotype and responses to therapy. Nature Medicine, 19:619-625, 2013.

Young, K., Lawlor, R.T., Ragulan, C., Patil, Y., Mafficini, A., Bersani, S., Antonello, D., Mansfied, D., Cingalini, S., Landoni, L., Pea, A., Luchini, C., Piredda, L., Kannan, N., Nyamundanda, G., Morgenstein, D., Chau, I., Wiedenmann, B., Milella, M., Melcher, A., Cunningham, D., Starling, N., Scarpa, A*., Sadanandam, A*. Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumors. Gut, 0:1-10; 2021. *- co-corresponding authors.

Wilkins, A., Fontana, E., Nyamundanda, G., Ragulan, C., Patil, Y., Mansfield, D., Kingston, J., Errington-Mais, F., Bottomley, D., von Loga, K., Bye, H., Carter, P., Tinkler-Hundal, E., Noshirwani, A., Downs, J., Dillon, M., Demaria, S., Sebag-Montefiore, D., Harrington, K., West, N., Melcher, A., Sadanandam, A. Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer. Journal of ImmunoTherapy and Cancer, e001717, 2021.

Smyth, E. C., Nyamundanda, G., Cunningham, D., Fontana, E., Ragulan, C., Tan, I. B., Lin, S. J., Wotherspoon, A., Nankivell, M., Fassan, M., Lampis, A., Hahne, J., Davies, A., Lagergren, J., Gossage, J., Maisey, N., Green, M., Zylstra, J., Allum, W., Langley, R. E., Tan, P., Valeri, N., Sadanandam, A. A 7-gene Signature Assay Improves Prognostic Risk Stratification of Perioperative Chemotherapy Treated Gastroesophageal Cancer Patients from the MAGIC Trial. Annals of Oncology 29(12):2356-2362, 2018.

Sadanandam, A*., Wullschleger, S., Lyssiotis, C., Grotzinger, C., Barbi, S., Bersani, S., Korner, J., Wafy, I., Mafficini, A., Lawlor, R.T., Asara, J.M., Blaker, H., Cantley, L.C., Wiedenmann, B., Scarpa, A*., and Hanahan, D*. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive metastatic, developmental, and metabolic characteristics. Cancer Discovery, 5; 1296-1313, 2015. *- co-corresponding authors.

Woolston, A., Khan, K, Spain, G, Barberm LJ., Griffiths, B., Gonzalez-Exposito, R., Hornsteiner, L., Punta, M., Patil, Y., Newey, A., Mansukhani, S., Davies, M.N., Furness, A., Sclafani, F., Peckitt, C., Jiménez, M,. Kouvelakis, K., Ranftl, R., Begum, R., Rana, I., Thomas, J., Bryant, A., Quezada, S., Wotherspoon, A., Khan, N., Fotiadis, N., Marafioti., T, Powles, T., Lise, S., Calvo, F., Guettler, S., von Loga, K., Rao, S., Watkins, D., Starling, N., Chau, I., Sadanandam, A., Cunningham, D., Gerlinger, M. Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-egfr treatment in colorectal cancer. Cancer Cell 36(1):35-50, 2019.

Neuzillet, C *. , Tijeras-Raballand., A, Ragulan, C., Cros, J., Patil, Y., Martinet, M.,  Erkan, M., Kleeff, J., Wilson, J., Apte, M.,  Tosolini, M., Wilson, A.S., Delvecchio, F.R., Bousquet, C., Paradis, V., Hammel, P., Sadanandam, A * ., Kocher, H.M * . Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. Journal of Pathology, 248(1):51-65, 2019. * - co-corresponding authors. – Awarded Jass Prize.

Sadanandam, A., Varney, ML., Singh, S., Ashour, AE., Moniaux, N., Deb, S., Lele, SM., Batra, SK., Singh, RK. High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. International Journal of Cancer, 127(6); 1373-83, 2010.

Borelli, B*., Fontana, E*., Gordano, M., Antoniotti, C., Bergamo, F., Murgioni, S., Pietrantonio, F., Morano, F., Tamburini, E., Boccaccino, A., Santini, D., Conca, V., Pella, N., Maiello, E., Ugolini, C., Fontanini, G., Falcone, A., Nyamundanda, G., Sadanandam, A#., Cremolini, C#. Prognostic and predictive impacts of Consensus Molecular Subtypes and CRCAssigner classifications in metastatic colorectal cancer: a translational analysis of the TRIBE2 study. ESMO Open, 6(2):100073, 2021. # - co-corresponding authors. * - co-first authors.

Fontana, E., Nyamundanda, G., Cunningham, D., Tu, D., Chong, M.C.C., Jonker, D.J., Siu, L.L., Sclafani, F., Eason, K., Ragulan, C., Bali, M.A., Hulkki-Wilson, S., Loree, J.M., Waring, P.M., Giordano, M., Lawrence, P.V., Rodrigues, D.N., Begum, R., Shapiro, J., Price, T.J., Cremolini, C., Starling, N., Pietrantonio, F., Trusolino, L., O'Callaghan, C., Sadanandam , A. Intra-tumoural transcriptome heterogeneity is associated with patient prognosis and sidedness in colorectal cancer patients treated with anti-EGFR therapy from the CO.20 trial. JCO Precision Oncology, 4; 1152-1162; 2020.

Nyamundanda, G., Eason, K., Guinney, J., Lord, C.J., Sadanandam, A. A Machine-Learning Tool Concurrently Models Single Omics and Phenome Data for Functional Subtyping and Personalized Cancer Medicine. Cancers, 12(10):2811; 2020.

Nyamundanda, G., Poudel, P., Patil, Y. and Sadanandam, A. A novel statistical method to diagnose, quantify and correct batch effects in genomic data. Nature
Scientific Reports, 7; 10849, 2017.

Ragulan, C., Eason, K., Fontana, E., Nyamundanda, G., Tarazona, N., Patil, Y., Poudel, P., Lawlor, R.T., Del Rio. M., Si-Lin, K., Wah Siew, T., Slcafani, F., Begum, R., Teixeira Mendes, L.S., Martineau, P., Scarpa, A., Cervantes, A., Tan, I.B., Cunningham, D., Sadanandam, A. Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer into Molecular Subtypes. Nature Scientific Reports 9(1):7665, 2019.

Review

1. Nyamundanda, G., Fontana, E., Sadanandam, A. Is the tumour microenvironment a critical prognostic factor in early-stage colorectal cancer? Annals of Oncology, 2019 (Editorial).

2. Fontana, E., Eason, K., Salazar, R., Cerventes, A., Sadanandam, A. Context Matters - Consensus Molecular Subtypes of Colorectal Cancer as Biomarkers for Clinical Trials. Annals of Oncology, 30(4):520–527, 2019.

3. Bijlsma, M.F., Sadanandam, A., Tan, P. and Vermuelen, L. Molecular Subtypes in cancers of the gastrointestinal tract. Nature Reviews Gastroenterology and Hepatology, 14:333-342, 2017 (invited review).

4. Herpels, M., Ishihara, J., Sadanandam, A. The clinical terrain of immunotherapies in heterogenous pancreatic cancer: unravelling challenges and opportunities. Journal of Pathology, 260:533-550, 2023.

5. Eason, K., and Sadanandam, A. Molecular or metabolic reprogramming: what triggers cancer subtypes? Cancer Research, 5: 76(18):5195-5200, 2016 (invited review).

6. Young K, Starling N, Sadanandam A. The molecular biology of pancreatic neuroendocrine neoplasms: Challenges and translational opportunities. Seminar in Cancer Biology, 61; 132-138, 2020 (invited review).