Zoom-In on Champalimaud: Liad Hollender

For many years, corneal injuries or disorders have been one of the leading causes of blindness across the world. The two physician-scientists have decisively changed and accelerated the path to the treatment of these problems. A deeper understanding of the transparent outer layer of the eye, as well as the possibility of ensuring an improved and more cost-effective approach to corneal surgery and transplantation, are essential to tackle this plight.

The statistics for pancreatic cancer are sobering. With a five-year survival rate of only 9%, incidence of the most common type, pancreatic ductal adenocarcinoma (PDAC), is growing and projected to be the second cause of cancer deaths by 2030. Surgery remains the most effective treatment, yet for 70-80% of patients, surgery is not a viable option. Understanding pancreatic cancer at the cellular and subcellular level is essential for developing therapies that can buy patients more time.
 

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Scientific Article

One of the hallmarks of multiple myeloma (MM), a cancer of the bone marrow and one of the most frequent haematological cancers worldwide, is the disruption of the patients’ immune system, which allows the cancer to progress. Now, a study performed by Cristina João, who leads the Myeloma and Lymphoma Research Group at the Champalimaud Centre for the Unknown, and her colleagues, shows how so-called extracellular vesicles (EV’s) released by multiple myeloma cells can drive the disruption of the immune system.