Here, we highlight the observations, the questions, the approaches and strategies that showcase the creativity and critical thinking inherent in scientific research.

In science, creativity stands as a crucial, albeit sometimes underappreciated, skill. Creativity comes in a wide variety of forms and shapes, and often emerges from collaborative interactions among diverse minds, emphasising the importance of inclusivity and varied perspectives in driving forward groundbreaking research.

For some time now, the IARC (International Agency for Research on Cancer), the world’s body that defines carcinogens, has considered night shift work as a potential carcinogen.

But what about the general population of adults that are not night-shift workers and that sleep too little or go to bed too late – or have “poor quality" sleep, waking up repeatedly during the night? Are they also at an increased risk of cardiovascular disease or cancer and are therefore more likely to die prematurely than people whose sleep patterns are considered healthier?

Whenever we look at the world in front of us, light falls onto our retina and is processed in a series of steps in the brain. The primary visual cortex is the first stage in the cerebral cortex, where visual information is processed. Nevertheless, neurons here do not only respond to patterns of light, but to sounds as well. A major question in the field, however, has been whether these responses truly represent auditory information, or are instead modulations due to body movements elicited by the sounds.

We are used to hearing about vaccines that prevent diseases, protecting us from them before we ever catch them. They train the immune system to recognise and fight common bacteria and viruses. One or several shots suffice to ensure that, when we are actually confronted with the danger, our body’s immune system will produce the right cells and antibodies to protect us: the disease will be prevented before it ever affects our body. Sometimes the vaccine’s effects are lifelong, in other cases you need a periodical boost to maintain a strong level of immunity.

In November 2023, a meeting on malignant melanoma, entitled "Challenging Malignant Melanoma", was held at the Champalimaud Foundation. It was organised by the Dermatology Unit and aimed at doctors and researchers from various specialisations. The organisers consider it a success and intend to repeat this type of event to bring together clinical and scientific expertise.

Slated to begin recruiting patients in 2025, the PsyPal study represents a significant step in exploring innovative treatments for deep psychological and existential distress in those with advanced illnesses. The CF, alongside three other European clinical sites, will treat over one hundred patients, each site focusing on a different condition.

The ERC Proof of Concept Grant is awarded exclusively to Principal Investigators who have previously won an ERC grant. Its primary goal is to support the commercial and social innovation potential of ERC-funded research. “It takes courage and skill to take an idea from the lab into the world of business. The Proof of Concept grants announced today are designed to enable researchers to take this brave step and transform groundbreaking research into tangible innovations”, remarked Iliana Ivanova, European Commissioner for Innovation, Research, Culture, Education and Youth.

The objective of this partnership will be focused on research and improvement of medicine dedicated to the treatment of patients with pancreatic cancer.

This collaboration will reinforce scientific exchange between the two institutions and will be led by doctors and researchers from both institutions such as Carlos Carvalho and Sherman Moreira from the Champalimaud Foundation, and Gustavo Guimarães, Bendito Rossi and Fabio Kater from Beneficência Portuguesa de São Paulo.

“HALLO,” Robin typed on the keyboard.
“HALLO, HOW ARE YOU FEELING?” replied ELIZA, the printed words appearing instantly on the VDU [computer screen]. 
“I’M FEELING TERRIBLE,” Robin replied. 
“WHAT DO YOU MEAN BY THAT PRECISELY?” 
“I’M FEELING DEPRESSED.” 
“WHY DO YOU THINK YOU ARE DEPRESSED?”
“BECAUSE I’M LONELY.” 
“DO YOU LIVE WITH YOUR FAMILY?”
“NO.”
“DO YOU HAVE ANY FRIENDS?” 
“NOT REALLY.” 
“WHY IS THAT?”

But it isn’t only a skin cancer: there exist other, though much rarer, forms of malignant melanoma that can develop in other parts of the body.

For instance, mucosal melanoma occurs on mucous membranes, which line various cavities in the body. Mucosal melanomas can be found in the head and neck, the anorectal region, the vulvovaginal region and the urinary tract. These melanomas have a poorer prognosis than skin melanomas.