“Surgery can cure”, said Markus Büchler, director of the newly opened Botton-Champalimaud Pancreatic Cancer Centre, in Lisbon, during his talk. Büchler was referring to a form of pancreatic cancer surgery called the “triangle operation”, which he invented and developed.

The Champalimaud Foundation's Breast Cancer Research Programme is made up of groups dedicated to all aspects related to the disease, from diagnosis to treatment. The goal is to improve the quality of life and survival of patients by utilising cutting-edge technologies that combine new techniques and methods with clinical practice to better serve patients.

Natural ageing is one of the main risk factors for cancer. As we become older, the probability of developing cancer increases. This happens, on the one hand, because the probability of acquiring cancer-causing mutations grows as we live longer; and on the other, because our DNA repair mechanisms decline with age.

Here are some recurrent unproven claims:

Experts from two international nuclear medicine societies (EANM and SNMMI) have joined those from important societies of various other medical specialities involved in the care of breast cancer patients – including oncology, surgery, radio-oncology and breast imaging – to draw up a set of recommendations, based on scientific evidence, on the correct utilisation, in breast cancer, of a medical imaging exam. The exam in question has been used for several years and involves radioactive substances, in this case a glucose analogue called fluorodeoxyglucose (FDG).

Given that nursing is mostly a female profession, why are management positions mostly held by men?
 
The question was asked by Carla Martins, director of nursing at the Local Health Unit of Santa Maria Hospital, in Lisbon, during a recent debate at the Champalimaud Foundation (CF) on gender equality and, more specifically, on female leadership in healthcare.
 

There are varying degrees in the response of a cancerous tumour to a treatment. A complete response corresponds to the disappearance of all detectable signs of cancer in the body, while a partial or incomplete response is a decrease in the size of the tumour or in the amount of cancer in the body. To be considered a partial response, the measurable size of the tumor has to be reduced by at least 30% to 50% due to the treatment. 

A strategy called Watch & Wait (W&W) has increasingly been used, including at the Champalimaud Foundation, to avoid surgery and its associated complications, in a selected group of patients  whose tumours become undetectable after chemoradiotherapy. In terms of the local tumour control, it has been shown to be as safe to operate them later – if ever their tumour gives any sign of coming back – as to operate them immediately after chemoradiotherapy treatment.

Cancers become resistant to chemotherapy in two major ways. They either have preexisting resistance to a type of drug or they can develop resistance through mutations.

Here are some of the main reasons for cancer drug resistance to arise. 

Here, we highlight the observations, the questions, the approaches and strategies that showcase the creativity and critical thinking inherent in scientific research.

In science, creativity stands as a crucial, albeit sometimes underappreciated, skill. Creativity comes in a wide variety of forms and shapes, and often emerges from collaborative interactions among diverse minds, emphasising the importance of inclusivity and varied perspectives in driving forward groundbreaking research.