Using zebrafish “Avatars”, an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine’s action on bladder cancer cells.

Now, Megan Carey from the Champalimaud Foundation (CF), Mónica Sousa from the Instituto de Investigação e Inovação em Saúde (i3S), Ricardo Henriques from the Instituto Gulbenkian de Ciência (IGC), and Rui Oliveira from IGC and the Instituto Universitário de Ciências Psicológicas Sociais e da Vida (ISPA), become EMBO Mem

Artificial intelligence (AI) is a spectacular tool that has been in development for the last decades; its role in our lives is already pervasive and will inevitably grow; and, most importantly, we can, through regulation, avoid its abuses (such as fake news and the manipulation of human beings). Indeed, whatever the future of AI is to be, we have the power to choose – wisely – to use it for the common good.

Rita Fior, leader of the Cancer Development and Innate Immune Evasion Group at the Champalimaud Foundation (CF), has been studying for several years the power of zebrafish “avatars”, or zAvatars, of cancer patients to help guide therapeutic decisions. The goal: to predict individual cancer treatment outcomes, thus enabling the selection of the best available chemotherapy treatment for each patient.

Every day, we make countless decisions based on sounds without a second thought. But what exactly happens in the brain during such instances? A new study from the Renart Lab, published in Current Biology, takes a look under the hood. Their findings deepen our understanding of how sensory information and behavioural choices are intertwined within the cortex — the brain’s outer layer that shapes our conscious perception of the world.

“When I explain to my friends and family the rigorous regulations in place to ensure ethical treatment of experimental animals, they seem surprised.
 
It is important that people know that researchers that use animals are obliged to have appropriate qualifications and training. That scientific projects are evaluated to ensure that the use of animals is needed, beneficial and that no unnecessary harm is inflicted. And that the highest standards of housing conditions must be provided by the facilities where animals are housed.
 

A study published in mid-April in the journal Nature Communications by Leopoldo Petreanu and his team, from the Cortical Circuits lab at Champalimaud Research, concludes that sensory processing by the visual cortex’s is not purely visual. More to the point, the study shows that, right from the early stages of sensory processing, the visual cortex integrates information from other sensory modalities, such as sounds.

Part I of the series of Ar Events under the motto “Roots of AI” was about the past – the history of artificial intelligence". Now, the “Creative Directors” and the invited speakers of Part II of the series, which took place at the Champalimaud Foundation (CF) last month, undertook to discuss the now of AI, sharing their views on the pros and cons of the technology. Part III (the last event of the series) will take place on May 7th and will deal with the future of AI.

Reported today in Science, the researchers found that mice given a diet rich in vitamin D had better immune resistance to experimentally transplanted cancers and improved responses to immunotherapy treatment. This effect was also seen when gene editing was used to remove a protein that binds to vitamin D in the blood and keeps it away from tissues.

This Sunday, April 14th, to commemorate four years since her passing, the Champalimaud Foundation honoured the memory of researcher Maria de Sousa, renowned globally as a pivotal figure in the field of Immunology.

The ceremony took place at the Champalimaud Foundation, with the inauguration of an exhibition showcasing an art collection by Pedro Cabrita Reis, representing Maria de Sousa's research and inspired by her curiosity and permanent quest for knowledge.