Why Adult Plasticity Matters

Much like young children who swiftly acquire languages in their early years, our visual system also has a “critical period” during the first few years of life where rapid development occurs. After this time, changes become more difficult, following the old adage, “You can’t teach an old dog new tricks”. Indeed, many treatments aimed at restoring vision, such as those addressing congenital cataracts or “lazy eye”, are only effective before the age of 7.

From Aristotle’s musings on the nature of time to Einstein’s theory of relativity, humanity has long pondered: how do we perceive and understand time? The theory of relativity posits that time can stretch and contract, a phenomenon known as time dilation. Just as the cosmos warps time, our neural circuits can stretch and compress our subjective experience of time. As Einstein famously quipped, “Put your hand on a hot stove for a minute, and it seems like an hour. Sit with a pretty girl for an hour, and it seems like a minute”.

The 2023 retreat took place at the Grande Hotel do Luso, in the beautiful Serra do Buçaco, from 29 May to 1 June, with the participation of more than 250 CR members. The theme of this year’s retreat was Embracing Multitudes: a Game of Translation which aimed at building bridges between the diverse research areas of CR, from neuroscience, cancer biology and immunology, to translational clinical research. The focus was on the diversity that shapes our institute and how to create a cohesive and collaborative community.

Interview with Nikos Papanikolaou, principal investigator of the Computational Clinical Imaging Group.

The exploration of alternative therapeutics for hard-to-treat mental health disorders has brought into focus an array of psychedelics such as psilocybin, present in ‘magic mushrooms’, and LSD, substances once associated more with counterculture than clinical practice. Alongside ‘atypical’ psychedelics like ketamine and MDMA, these substances are increasingly being recognised for their potential therapeutic attributes.

The Constant Chatter of Neurons

“The brain isn’t like a computer that turns off when it’s not doing a particular task”, explains Alfonso Renart, the senior author of the study published in eLife. “There’s always a kind of background hum, a baseline activity that can sometimes make it seem as if the brain is chattering to itself”. The team’s study lifts the lid on how that baseline activity, the continuous stream of electrical impulses sent by neurons, impacts behaviour and decision-making.

Many animals rely on smell to identify and locate objects in their surroundings and to respond appropriately. To investigate this phenomenon further, Greg Jefferis’ group in the LMB’s Neurobiology Division established a collaboration with the Behavior and Metabolism Lab, lead by Carlos Ribeiro, at the Champalimaud Foundation (CF) and the group of  Drosophila Connectomics at Cambridge University and together studied Drosophila flies.

The work, recently published in prestigious scientific journal PNAS, also shows that this molecule, which is transported by extracellular vesicles produced by tumor cells, directs these vesicles to the liver and lung, precisely the organs where it is common for stomach cancer metastases to appear. With these discoveries, the team contributed to the understanding of a new communication mechanism of tumor cells, thus identifying a potential new goal in developing targeted therapies to stop metastasis.

A study published today, April 13th, in the journal Nature Neuroscience provides a surprising answer to this question by showing that, rather than committing to a single strategy, the brain can compute multiple alternative decision strategies simultaneously.

The study, led by Fanny Cazettes and senior authors Zachary Mainen and Alfonso Renart, at the Champalimaud Foundation in Lisbon, Portugal, performed a specially-designed experiment which used a kind of “virtual reality” setup for mice, in which the animals were tasked with searching for water in a virtual world. 

In Portugal, the winning scientists are Isabel Gordo (Gulbenkian Institute of Science, IGC), Maria Manuel Mota (João Lobo Antunes Institute of Molecular Medicine, iMM), Mariana Pinho (ITQB-NOVA) and Henrique Veiga-Fernandes (Champalimaud Foundation). Each will receive between €2.5M and €3.5M for the development of research projects over the next five years.