A side-effect “is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant”. 

Interview with António Parreira, Clinical Director of the Champalimaud Clinical Centre

Has there been an increase in the number of cancer cases? What is the reason for this?

We know that there has indeed been an increase. The question is to try to understand how we can, not only understand this phenomenon, but also, somehow, minimise its effects.

This phenomenon has to do with ageing. The development of cancers is one of the very direct consequences of ageing.

That said, this definition has been widening throughout the years to include potential chemopreventive substances that are not necessarily drugs. So-called “nutraceuticals”, such as dietary fiber, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants (such as vitamins) and different types of herbal or natural foods (dietary supplements) are also being studied for cancer chemoprevention. However, to date, the efficacy of these substances has not been confirmed.

In CheckUp #14, we talked about the different types of cancer treatments with ionizing radiation: internal and external radiotherapies. We promised we would return to this subject to talk in more detail about a special type of internal radiotherapy: molecular radiotherapy. This activity is integrated in Nuclear Medicine, a medical specialty that, in Oncology, uses radiopharmaceuticals to diagnose, treat, and evaluate the response of cancers to existing or new drugs.

The Champalimaud Foundation has an experimental robot called Wingy, which runs Chat GPT and is expected one day to be able to greet patients who come to its Clinical Centre. But will Wingy replace the people currently in charge of that job?, asked Pedro Garcia da Silva, neuroscientist and Scientific Coordinator at Champalimaud Research, during his talk at the Champalimaud Cancer Nurse Conference, which took place at the Foundation on May 19th. 

Radiotherapy, or radiation therapy, is one of the pillars of cancer treatment. Radiotherapy preferentially uses X-rays to eliminate the solid manifestations of malignant tumours. 

It is estimated that 60% of cancer patients are treated with radiotherapy at a given phase of their disease, either as part of radical therapeutics (ablative) protocols or of symptomatic and palliative protocols.

Interview with Henrique Nabais and Filipa Silva on the occasion of World Ovarian Cancer Day, celebrated on May 8th. 

Ovarian cancer is the eighth most frequent cancer and the seventh most prevalent cause of death by cancer in women. In Portugal, in 2020, 560 new cases were diagnosed, and 408 deaths occurred, proving that this relatively rare cancer is highly lethal.

Maria (fictional name) has a scheduled surgical intervention to remove a malignant tumour from one of her breasts. She is the pre-op room, waiting to go into the OR, where the surgery will be performed under general anaesthetics. No wonder she feels anxious, her heart beats very fast, and she is unable to think about anything else right now. Her blood pressure is also going up.

Carla Malveiro is responsible, at the Champalimaud Foundation (FC), for implementing oncological patients’ physical exercise programmes, particularly for women undergoing treatment at the Foundation’s Breast Unit. As a doctoral student from the Human Motricity Faculty (FMH) of the University of Lisbon, the 41-year-old exercise physiologist, specialising in oncology, has worked at the Foundation since October.

March was Multiple Myeloma Awareness Month. In this short video, Cristina João, Haemato-oncologist of the Haemato-oncology Unit at the Champalimaud Foundation, explains what this pathology is and talks about the activities that the Unit has developed for improving the care of people with Multiple Myeloma. She also points out that, in addition to clinical activity, the Haemato-Oncology Unit does translational research through the Foundation's Lymphoma and Myeloma Research Group, which she leads.