Developed by an international consortium of 117 experts in legal, ethical, clinical, and AI domains—and featuring Champalimaud Foundation (CF) Principal Investigator Nikolas Papanikolaou—the framework provides a detailed roadmap for creating trustworthy medical AI, from the earliest design stages all the way through clinical deployment and monitoring.

It all began with a little theatre play.

Three women working in  neuroscience walk into the stage. They have to decide what will be the topic of the next Ar Event. After some discussion, they settle on the theatre. How does neuroscience explain what happens when people watch actors perform?, they want to know. So they put their white labcoats on to better think scientifically. 

Each year, the European Association for the Study of Obesity (EASO) and the Novo Nordisk Foundation, honours exceptional research contributions that enhance our understanding of obesity, its causes, complications, prevention, and management. 

A new study from researchers at the Champalimaud Foundation (CF) investigated whether artificial intelligence (AI) could analyse MRI scans to reliably tell which cancers are less aggressive and which pose a greater risk. While AI showed promise, its accuracy varied significantly depending on the MRI scanner’s brand.

An international team, co-led by Adriana Sánchez-Danés, principal investigator of the Cancer and Stem Cell Biology Lab at the Champalimaud Foundation, in Lisbon, has shown for the first time the important role of Survivin – a protein that has key roles in regulating cell division and inhibiting apoptosis (programmed cell death) – in the initiation and formation of a basal cell carcinoma, the most common human skin cancer. Their results have now been published in the print edition of January 8, 2025, of the journal Cell Discovery.

An international team of scientists, including a principal investigator in neuroscience from the Champalimaud Foundation, in Lisbon, has analysed the way expert London taxi drivers plan their route in advance every time they pick up passengers. It is the first time a study about human planning has been performed in a real-world, large-scale environment. Their results are published today (23rd of January) in the Proceedings of the National Academy of Sciences. 

Over the past decade, interest in psychedelics—including psilocybin, LSD, and MDMA—as treatments for psychiatric disorders has grown exponentially among scientists, mental health professionals, the media, and the public.

During periods of low energy—such as intermittent fasting or exercise—immune cells step in to regulate blood sugar levels, acting as the “postman” in a previously unknown three-way conversation between the nervous, immune and hormonal systems. These findings open up new approaches for managing conditions like diabetes, obesity, and cancer.

Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a significant impact on young people and their families as treatment can require surgery or amputation. The cancer also has the potential to spread to other organs, most commonly the lungs. Because osteosarcoma is so genomically complex, it has been challenging to identify what genetic mutations drive the disease.

Water is the matrix of our planet. Not only human societies, but all forms of life, are dependent on water. And while we still take its availability largely for granted, it is a resource which is becoming scarcer by the minute owing to climate change,  intensive agriculture, and access inequalities to water for drinking, cooking, and personal hygiene.